Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
Identifieur interne : 000095 ( France/Analysis ); précédent : 000094; suivant : 000096Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
Auteurs : Julien Chapuis ; Frdric Moisan ; Georges Mellick ; Alexis Elbaz ; Peter Silburn ; Florence Pasquier ; Didier Hannequin [France] ; Corinne Lendon ; Dominique Campion [France] ; Philippe Amouyel ; Jean-Charles Lambert [France]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2008-09-15.
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD casecontrol studies (n 3176) and two independent PD casecontrol studies (n 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.
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DOI: 10.1093/hmg/ddn183
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Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD casecontrol studies (n 3176) and two independent PD casecontrol studies (n 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Rouen</li></settlement></list><tree><noCountry><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Chapuis, Julien" sort="Chapuis, Julien" uniqKey="Chapuis J" first="Julien" last="Chapuis">Julien Chapuis</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><name sortKey="Mellick, Georges" sort="Mellick, Georges" uniqKey="Mellick G" first="Georges" last="Mellick">Georges Mellick</name><name sortKey="Moisan, Frdric" sort="Moisan, Frdric" uniqKey="Moisan F" first="Frdric" last="Moisan">Frdric Moisan</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Silburn, Peter" sort="Silburn, Peter" uniqKey="Silburn P" first="Peter" last="Silburn">Peter Silburn</name></noCountry><country name="France"><noRegion><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name></noRegion><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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